Side effects of inhaled corticosteroids in copd

The most common side effects with inhaled steroids are thrush (a yeast infection of the mouth or throat that causes a white discoloration of the tongue), cough or hoarseness. Rinsing your mouth (and spitting out the water) after inhaling the medicine and using a spacer with an inhaled metered-dose-inhaler reduces the risk of thrush. When a dose is prescribed that is normal or higher than the normal dose in the package insert, some systemic side effects may occur. Keep in mind, however, that an inhaled steroid has much less potential for side effects than steroid pills or syrups. There have been concerns regarding the possibility of growth suppression in children.  Recent studies have not shown growth suppression over several years of treatment.

Poor Growth: While poor growth can result from ICS, poorly controlled asthma can also lead to poor growth in children. In general, low and medium doses of ICS are potentially associated with small, non-progressive but reversible declines in growth of children. As a result, you and your asthma provider should not only carefully monitor growth, but try to use the lowest possible dose that gets good control of your child's asthma. You must weigh the potential benefits of good asthma control with the small but real possible side effect of slowed growth.

In a long-term safety trial in patients 12 years and older treated for 52 weeks with DULERA 100 mcg/5 mcg (n=141), DULERA 200 mcg/5 mcg (n=130) or an active comparator (n=133), safety outcomes in general were similar to those observed in the shorter 12 to 26 week controlled trials. No asthma-related deaths were observed. Dysphonia was observed at a higher frequency in the longer term treatment trial at a reported incidence of 7/141 (5%) patients receiving DULERA 100 mcg/5 mcg and 5/130 (%) patients receiving DULERA 200 mcg/5 mcg. No clinically significant changes in blood chemistry, hematology , or ECG were observed.

The growth of children and adolescents receiving orally inhaled corticosteroids, including QVAR, should be monitored routinely (., via stadiometry). If a child or adolescent on any corticosteroid appears to have growth suppression, the possibility that he/she is particularly sensitive to this effect should be considered. The potential growth effects of prolonged treatment should be weighed against clinical benefits obtained and the risks associated with alternative therapies. To minimize the systemic effects of orally inhaled corticosteroids, including QVAR, each patient should be titrated to his/her lowest effective dose [see Dosage and Administration ( )] .

Side effects of inhaled corticosteroids in copd

side effects of inhaled corticosteroids in copd

The growth of children and adolescents receiving orally inhaled corticosteroids, including QVAR, should be monitored routinely (., via stadiometry). If a child or adolescent on any corticosteroid appears to have growth suppression, the possibility that he/she is particularly sensitive to this effect should be considered. The potential growth effects of prolonged treatment should be weighed against clinical benefits obtained and the risks associated with alternative therapies. To minimize the systemic effects of orally inhaled corticosteroids, including QVAR, each patient should be titrated to his/her lowest effective dose [see Dosage and Administration ( )] .

Media:

side effects of inhaled corticosteroids in copdside effects of inhaled corticosteroids in copdside effects of inhaled corticosteroids in copdside effects of inhaled corticosteroids in copdside effects of inhaled corticosteroids in copd