Two Phase 3 identically designed, multi-center, vehicle-controlled, double-blind studies were conducted to evaluate the clinical safety and efficacy of Carac (fluorouracil) . Patients with 5 or more actinic keratoses (AKs) on the face or anterior bald scalp were randomly allocated to active or vehicle treatment in a 2:1 ratio. Patients were randomly allocated to treatment durations of 1, 2, or 4 weeks in a 1:1:1 ratio. They applied the study cream once daily to the entire face/anterior bald scalp. Each patient's clinical response was evaluated 4 weeks after the patient's last scheduled application of study cream. No additional post-treatment follow-up efficacy or safety assessments were performed beyond 4 weeks after the last scheduled application. The following graphs show the percentage of patients in whom 100% of treated lesions cleared, and the percentage of patients in whom 75% or more of treated lesions cleared. Treatment with Carac (fluorouracil) cream for 1, 2, or 4 weeks is compared to treatment with vehicle cream. Outcomes from 1, 2, and 4 weeks of treatment with vehicle cream are pooled because duration of treatment with vehicle had no substantive effect on clearance. Results from the two Phase 3 studies are shown separately. Although all treatment regimens of Carac (fluorouracil) studied demonstrated efficacy over vehicle for the treatment of actinic keratosis , continuing treatment up to 4 weeks as tolerated results in further lesion reduction and clearing.
Advantages an Ostarine cycle has over a Epi cycle:
-There is no need for pre cycle supports such as Hawthorn berry.
-There is no need for on cycle supports such as milk thistle for the liver, policosanolor RYR for cholesterol etc.
-Some supression may be present at doses of 25mg+ run for longer than 4 weeks, however a stringent PCT of prescription SERMs like Nolva or Clomid are not necessary.
-High oral biovailabilty without the damage to your liver as with the methylated Epi.
-Great sense of well being while on, with out the agression which can often detrimentally impact users daily lifes).
-No need for a long time period off between cycles, the recomended time of period for Tren would be Time on +PCT, so for a typical 6 week cycle and 4 week PCT, a user would have to wait another 10 weeks after PCT to start another cycle.
-The response rate (users who make gains from Epi) is also very hit and miss.