Salicylates are derivatives of salicylic acid that occur naturally in plants and serve as a natural immune hormone and preservative , protecting the plants against diseases , insects , fungi , and harmful bacteria . [ citation needed ] Salicylates can also be found in many medications , perfumes and preservatives. [ citation needed ] Both natural and synthetic salicylates can cause health problems in anyone when consumed in large doses, [ citation needed ] but for those who exhibit salicylate sensitivity (also known as salicylate intolerance ), even small doses of salicylate can cause adverse reactions.
Patients with Cancer Receiving Myelosuppressive Chemotherapy: White blood cell counts ≥ 100,000/mm 3 were observed in about 2% of patients who received NEUPOGEN ® at dosages > 5 mcg/kg/day. It is recommended that NEUPOGEN ® therapy be discontinued if the absolute neutrophil count (ANC) surpasses 10,000/mm 3 after the chemotherapy-induced ANC nadir has occurred. Monitor CBCs at least twice weekly during therapy. Dosages of NEUPOGEN ® that increase the ANC beyond 10,000/mm 3 may not result in any additional clinical benefit. Discontinuation of NEUPOGEN ® therapy usually resulted in a 50% decrease in circulating neutrophils within 1 to 2 days, with a return to pretreatment levels in 1 to 7 days.