The Oxandrolone hormone does not carry any estrogenic related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels. It further carries no progestin related activity, which again supports no estrogenic related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure. Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone , but Anavar is rarely associated with this trait.
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A subset of patients with ALD will develop severe AH, which has a substantially worse short-term prognosis (37). AH also represents a spectrum of disease, ranging from mild injury to severe, life-threatening injury, and often presents acutely against a background of chronic liver disease (38,39). The true prevalence is unknown, but histological studies of patients with ALD suggest that AH may be present in as many as 10–35% of hospitalized alcoholic patients (40–42). Typically, symptomatic patients present with advanced liver disease, with concomitant cirrhosis in more than 50% of the patients, and superimposed acute decompensation. However, even patients with a relatively mild presentation are at high risk of progressive liver injury, with cirrhosis developing in up to 50% of the patients (43,44). The likelihood that AH will progress to permanent damage is increased among those who continue to abuse alcohol. Abstinence from alcohol in one small series did not guarantee complete recovery. Only 27% of the abstaining patients had histological normalization, whereas 18% progressed to cirrhosis, and the remaining patients had persistent AH when followed for up to 18 months (45).