Dosis tinggi kortikosteroid

In the higher doses used to treat osteoporosis , plain sodium fluoride can cause pain in the legs and incomplete stress fractures when the doses are too high; it also irritates the stomach, sometimes so severely as to cause ulcers. Slow-release and enteric-coated versions of sodium fluoride do not have gastric side effects in any significant way, and have milder and less frequent complications in the bones. [30] In the lower doses used for water fluoridation, the only clear adverse effect is dental fluorosis , which can alter the appearance of children's teeth during tooth development ; this is mostly mild and is unlikely to represent any real effect on aesthetic appearance or on public health. [31] A chronic fluoride ingestion of 1 ppm of fluoride in drinking water can cause mottling of the teeth (fluorosis) and an exposure of ppm will produce mottling in 30–50 % of patients. [26]

Dosis tinggi kortikosteroid

dosis tinggi kortikosteroid

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